Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exogenous Progesterone as Ovulation Trigger
Sponsor: Instituto Valenciano de Infertilidade de Lisboa
Summary
The goal of this clinical trial is to learn whether the sudden administration of vaginal micronized progesterone during the late follicular phase can trigger an LH surge and reactivation of oocyte meiosis in healthy oocyte donors aged 18 to 33 undergoing a mild ovarian stimulation cycle. The main question it aims to answer is: * Does progesterone administered in the late follicular phase induce an LH surge and subsequent oocyte meiosis reactivation? Participants will: * Undergo a mild ovarian stimulation with 75 IU of follitropn alfa * Start vaginal micronized progesterone (400 mg every 12 hours) once at least one follicle reaches 15 mm * Have blood samples collected to measure hormone levels before and after progesterone administration * Undergo oocyte retrieval 35-36 hours after the progesterone trigger This is a low-intervention, single-center pilot study including approximately 10 oocyte donors.
Official title: Exogenous Progesterone as Ovulation Trigger - a Pilot Study
Key Details
Gender
FEMALE
Age Range
18 Years - 33 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-04
Completion Date
2026-06
Last Updated
2026-03-12
Healthy Volunteers
No
Conditions
Interventions
Vaginal micronized progesterone
This intervention consists of administering vaginal micronized progesterone at a dose of 400 mg every 12 hours to induce final oocyte maturation. The intervention is initiated once at least one follicle reaches a diameter of 15 mm during controlled ovarian stimulation with recombinant FSH. Progesterone administration continues until the morning of oocyte retrieval.
Locations (1)
Instituto Valenciano de Infertilidade (IVI Lisboa)
Lisbon, Portugal