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Optimisation of Solute Removal and Water Usage in Paediatric Haemodialysis
Sponsor: University Hospital, Ghent
Summary
Children receiving chronic haemodialysis are typically treated with dialysis machines designed for adult patients. As a result, some devices do not allow the ideal blood or dialysate flow rates to be set for paediatric use. In addition, the optimal dialysate-to-blood flow ratio for maximising solute removal while minimising water consumption remains poorly defined. The aim of this study is to quantify the dialyser extraction ratio and clearance across different dialysis modalities and a range of dialysate-to-blood flow ratios. Blood and dialysate samples are collected at the blood inlet, blood outlet, and dialysate outlet lines, and concentrations of various uraemic toxins-spanning a range of molecular weights-are measured to calculate solute clearances.
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-11-13
Completion Date
2026-12-31
Last Updated
2026-03-12
Healthy Volunteers
No
Interventions
blood and dialysate sampling
For ach setting, blood and dialysate samples are taken in order to be able to calculate the extraction ratio and dialyser clearance.
Locations (1)
Ghent University Hospital, Nephrology
Ghent, Belgium