Clinical Research Directory

Inclusion Criteria: 1. Mean resting heart rate ≤ 65 beats/min (based on a resting electrocardiogram). 2. Clinically confirmed right-sided heart failure, requiring ≥2 diuretic units to fully control edema, or having persistent grade ≥1 edema despite diuretic therapy. Diuretic unit definition: expressed as the number of daily doses at the standard oral dose. For example, the standard units for furosemide, torasemide, and spironolactone are 20 mg/day, 10 mg/day, and 20 mg/day, respectively. If a patient takes furosemide 20 mg twice daily and spironolactone 20 mg once daily, the total diuretic units equal 3. 3. Echocardiography shows severe or greater tricuspid regurgitation. 4. With/without an indication for permanent pacemaker implantation. 5. Is able to understand the purpose of the trial, voluntarily participates and signs written informed consent, and is willing to complete follow-up visits as required by the protocol. Exclusion Criteria: 1. Mean pulmonary artery pressure (mPAP) \> 35 mmHg measured by right heart catheterization at a pacing rate of 60 bpm. 2. Left ventricular ejection fraction (LVEF) \< 50% or left ventricular end-diastolic diameter (LVEDD) \> 56 mm as measured by echocardiography. 3. Prior implantation of a cardiac pacemaker. 4. Moderate or greater left-sided valvular regurgitation or stenosis. 5. Current use of heart rate-lowering medications, such as beta-blockers, digoxin, ivabradine, etc. 6. Untreated hypothyroidism. 7. Participation in another drug or medical device clinical trial that has not yet been completed. 8. Deemed unsuitable for participation in this clinical trial by the investigator.