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An Analysis of Healthy Caucasian Knees
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
In current literature, databases of healthy knee anatomy and function are confined to small sample sizes or singular imaging modalities. In this study, the investigator propose constructing a unique and large-scale database of healthy Caucasian knee anatomy and function by utilizing a combination of ultra-high resolution capabilities from photon-counting CT, lower limb weightbearing orthogonal imaging (EOS) of full leg, and non-invasive ultrasound-based functional testing of the knee. This study is a collaborative effort between the orthopaedics, radiology and biomechanical engineering departments in which the same prospectively acquired database will be used for multiple independent research questions.
Official title: An Analysis of Healthy Caucasian Knees: Variability in Threedimensional Anatomy, Mediolateral Ligamentous Balance, Lower Limb Alignment and Trabecular Micro-structure.
Key Details
Gender
All
Age Range
20 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-08-08
Completion Date
2027-01
Last Updated
2026-03-13
Healthy Volunteers
Yes
Conditions
Interventions
CT scan images of the knee
CT scan images of the knee allow for detailed anatomical analysis of joint shape through the means of statistical shape modelling.
EOS scan of full leg
Software-based reconstruction of orthogonal images provided by EOS imaging allows for a comprehensive three-dimensional analysis of lower limb alignment without the need for a full leg CT scan, minimizing exposure to ionizing radiation in the pelvic region.
Ultrasound-based gap analysis
For the analysis of constitutional balance, this study will use an ultrasound-based technique. This is a non-invasive and previously validated method of determining medio-lateral laxity of the knee joint.
Locations (1)
Universitaire Ziekenhuizen KU Leuven
Leuven, Vlaams-Brabant, Belgium