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Skin Involvement in Dupuytren Surgical Treatment Outcome
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult. Based on clinical experience in DD surgery and outcome, it is suspected that recurrence may be associated with such retracted skin. Possibly, this is due to presence and persistence of aligned myofibroblasts (MF), fixed to the deepest dermal layers. This interventional study aims to investigate the pathophysiological involvement of palmar skin in Dupuytren disease, and its implications for prognostics and treatment.
Official title: Skin Involvement in Dupuytren Surgical Treatment Outcome: Interventional Study on Prognostic Value of Cutometry, Ultrasound and Histopathology
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-12-10
Completion Date
2027-01-01
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
Suction cutometry
Suction cutometry is a non-invasive evaluation tool which is used to assess skin elasticity objectively and quantitatively.
Ultrasound measurement
Ultrasound measurement of distance between skin surface and underlying Dupuytren tissue
Microbiopsy for histological analysis
During microfasciectomy, the surgeon will perform a single-5mm microbiopsy of DD nodules with overlying skin in all patients. These biopsies will be preserved in the UZ/KU Leuven Biobank and immunohistochemical analyses will be performed.
Locations (1)
Universitaire Ziekenhuizen KU Leuven
Leuven, Vlaams-Brabant, Belgium