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MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI
Sponsor: Ankara Etlik City Hospital
Summary
In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \[TIMP-2\]\*\[IGFBP-7\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.
Official title: A MULTIMODAL APPROACH TO PREDICTING SEPSIS-RELATED ACUTE RENAL INJURY: A PROSPECTIVE COHORT STUDY
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2026-03-30
Completion Date
2027-01-30
Last Updated
2026-03-16
Healthy Volunteers
No
Interventions
Renal Resistive Index (RRI) Doppler Ultrasound
Doppler ultrasonography will measure RRI immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48).
Urinary TIMP-2 and IGFBP-7 biomarkers
Urine samples for \[TIMP-2\]\*\[IGFBP-7\] biomarker measurement will be collected immediately after sepsis diagnosis (T0) and 24 hours later (T24).