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pEEG-Guided Anesthesia and Behavioral Outcomes in Children
Sponsor: Istanbul University
Summary
Post-hospitalization behavioral changes are common in children after surgery and general anesthesia and may persist for varying durations depending on individual and perioperative factors. The Post-Hospitalization Behavior Questionnaire (PHBQ) is a well-validated instrument widely used to evaluate negative postoperative behavioral changes in pediatric patients following hospitalization or surgical procedures. Although early postoperative behavioral disturbances have been extensively studied, most research has focused on short-term outcomes within the first weeks after surgery, while long-term behavioral outcomes remain insufficiently investigated. Processed electroencephalography (pEEG) monitoring provides an objective method for assessing anesthetic depth during surgery. Parameters such as the Patient State Index (PSI) and Spectral Edge Frequency 95 (SEF95) allow dynamic evaluation of cortical activity and may help optimize anesthetic administration by preventing excessively deep or inadequate anesthesia. Improved anesthetic depth management may theoretically influence postoperative recovery and behavioral outcomes. In the initial randomized study, early postoperative behavioral assessments were obtained within the first postoperative month using the Post-Hospitalization Behavior Questionnaire (PHBQ). In the present follow-up study, children will be contacted again 12-24 months after surgery to evaluate long-term behavioral outcomes. PHBQ scores at long-term follow-up will be compared between children who previously received EEG-guided anesthesia and those managed with standard anesthesia without processed EEG monitoring. By examining both early and long-term behavioral outcomes, this study aims to determine whether intraoperative EEG-guided anesthesia management influences postoperative behavioral changes in the pediatric population.
Official title: Long-Term Behavioral Outcomes After pEEG-Guided Anesthesia in Children: A Follow-Up Study Using the Post-Hospitalization Behavior Questionnaire
Key Details
Gender
All
Age Range
3 Years - 10 Years
Study Type
INTERVENTIONAL
Enrollment
230
Start Date
2026-02-02
Completion Date
2026-08-22
Last Updated
2026-03-17
Healthy Volunteers
No
Interventions
Processed EEG Monitoring
Processed electroencephalography monitoring was used intraoperatively to guide anesthetic depth using Patient State Index (PSI)
Standard Anesthesia Management
Standard intraoperative anesthesia management without the use of processed EEG monitoring.
Locations (1)
Istanbul University
Istanbul, Istanbul, Turkey (Türkiye)