Clinical Research Directory

Inclusion Criteria: 1. Inclusion criteria for allogeneic hematopoietic stem cell transplantation shall be implemented in accordance with the regulations of the transplant center at the study site; 2. Patients undergoing allogeneic hematopoietic stem cell transplantation with any of the following high-risk factors for EBV infection: 1. EBV-DNA is positive in the recipient's or donor's serum, whole blood, PBMC or sorted cells before allogeneic hematopoietic stem cell transplantation; 2. EBV-DNA is positive in the recipient's whole blood, PBMC or sorted cells after allogeneic hematopoietic stem cell transplantation, but EBV-DNA in plasma is negative; 3. Allogeneic hematopoietic stem cell transplantation is performed due to treatment of EBV infectious diseases, including but not limited to: EBV-related lymphoma, chronic active EBV infection, EBV-related lymphoproliferative disorders, etc.; 4. There is a history of EBV infection in the past, and allogeneic hematopoietic stem cell transplantation is required due to other malignant diseases. 3. No age or gender restrictions; 4. The subject and the guardian understand and sign the informed consent form. Exclusion Criteria: 1. The exclusion criteria for allogeneic hematopoietic stem cell transplantation shall be implemented in accordance with the regulations of the transplant center at the study site; 2. Exclusion criteria before infusion of JYEST cell injection: 1. Severe kidney disease (creatinine clearance rate less than 50% of the normal reference value for the same age group); 2. Severe liver disease (TBil \> 2.0×ULN; ALT and AST \> 3.0×ULN); 3. Severe acute infection (opportunistic infection); 4. Expected survival period less than 6 weeks; 5. Malnutrition (weight ≤ 10th percentile for the same age group, or serum albumin ≤ 3.0 g/dL); 6. ECOG score \> 2.