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A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching an experimental drug called alirocumab, referred to as "study drug". In the United States, alirocumab is approved for the treatment of hypercholesterolemia (high blood cholesterol levels). The aim of the study is to see how safe and effective alirocumab is when given weekly to adult participants who have hypercholesterolemia. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug once a week * How much study drug is in the blood at different times
Official title: A Randomized, Open-Label, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Weekly Alirocumab in Adults With Hypercholesterolemia
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
420
Start Date
2026-06-17
Completion Date
2027-02-23
Last Updated
2026-07-08
Healthy Volunteers
No
Conditions
Interventions
Alirocumab
Administered per the protocol
Locations (30)
Anaheim Clinical Trials
Anaheim, California, United States
Cenexel CNS
Los Alamitos, California, United States
Diablo Clinical Research - Flourish Research
Walnut Creek, California, United States
Tampa Bay Medical Research
Clearwater, Florida, United States
Southwest General Healthcare Center
Fort Myers, Florida, United States
Precision Clinical Research
Sunrise, Florida, United States
K2 Medical Research The Villages
The Villages, Florida, United States
Center for Advanced Research and Education
Gainesville, Georgia, United States
Balanced Life Health Care Solutions
Lawrenceville, Georgia, United States
East-West Medical Research Institute
Honolulu, Hawaii, United States
L-MARC Research Center
Louisville, Kentucky, United States
Tandem Clinical Research
Marrero, Louisiana, United States
Mercury Street Medical Group, PLLC
Butte, Montana, United States
Velocity Clinical Research - Omaha
Omaha, Nebraska, United States
Palm Research Center, Mountainview Medical Center
Las Vegas, Nevada, United States
Velocity Clinical Research - Durham
Durham, North Carolina, United States
Ohio Clinical Trials
Columbus, Ohio, United States
AMR Norman
Norman, Oklahoma, United States
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States
Velocity Clinical Research, Medford
Medford, Oregon, United States
Altoona Center for Clinical Research
Duncansville, Pennsylvania, United States
Tribe Clinical Research
Greenville, South Carolina, United States
Coastal Carolina Research Center_North Charleston
North Charleston, South Carolina, United States
Velocity Clinical Research Dallas
Dallas, Texas, United States
Be Well Clinical Studies - Round Rock
Round Rock, Texas, United States
Flourish Research - San Antonio Medical Trials
San Antonio, Texas, United States
Endeavor Clinical Trials
San Antonio, Texas, United States
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Charlottesville Medical Research
Charlottesville, Virginia, United States
Rainier Clinical Research Center
Renton, Washington, United States