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Structured Physical Activity Intervention in Patients With MASLD Receiving a Mediterranean Diet
Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Summary
Lifestyle interventions based on diet and physical activity are the cornerstone of management for metabolic dysfunction-associated steatotic liver disease (MASLD), yet individual responses remain highly variable. Advanced imaging biomarkers and genetic profiling may help to characterize response patterns. This study aimed to evaluate the impact of a Mediterranean diet-based lifestyle intervention, with or without structured physical activity, on liver steatosis and fibrosis assessed by magnetic resonance imaging, and to identify determinants of treatment response.
Official title: Impacto de la Dieta Mediterránea Frente a la Dieta hipocalórica en la progresión de la Enfermedad hepática y el Riesgo Cardiovascular en Pacientes Con Enfermedad Hepática Metabólica Grasa. Búsqueda de Biomarcadores y Dianas terapéuticas
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
96
Start Date
2022-06-01
Completion Date
2023-10-31
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Exercise plus Mediterranean diet
Supervised exercise programme consisting of moderate-intensity aerobic activity and resistance training three times per week at a sports centre, plus counselling to follow a Mediterranean diet enriched with extra virgin olive oil.
At-home exercise plus Mediterranean diet
Moderate-intensity physical activity at home according to EASL recommendations, plus counselling to follow a Mediterranean diet enriched with extra virgin olive oil.
Locations (2)
Hospital Universitario Virgen del Rocío de Sevilla
Seville, Spain
Hospital Universitario de Valladolid
Valladolid, Spain