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Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study
Sponsor: University Hospital, Tours
Summary
The search for diagnostic biomarkers that can be used routinely is a major challenge to manage Amyotrophic lateral sclerosis (ALS) in order to characterize the pathophysiology and accelerate the management of the disease. Some non-specific biomarkers have been proposed (Neurofilaments, TDP-43) but their diagnostic value remains controversial. This study aims to identify ALS-specific platelet biomarkers using targeted and untargeted multi-omic approaches, in order to enable differential diagnosis between ALS and other motor neuron diseases.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2026-04
Completion Date
2027-08
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Locations (3)
University hospital, Limoges
Limoges, France
University hospital, Lyon
Lyon, France
university hospital, Tours
Tours, France