Clinical Research Directory

Inclusion Criteria: 1. Patients currently hospitalized 2. Laboratory confirmation of ARDS 3. Aged between 18 and 80 years 4. Willing and able to provide written informed consent, or with a legal representative who can provide informed consent 5. SpO2 \<94% on room air requiring supplemental oxygen above baseline 6. PaO2/FiO2 \<300 mmHg 7. Bilateral infiltrates on frontal chest radiograph or bilateral ground glass opacities on a chest CT scan 8. Requiring one of the following ï High Flow Oxygen Therapy ï Non-invasive Positive Pressure Ventilation (NIPPV, e.g. BiPAP and CPAP) ï Invasive Mechanical Ventilation (INV = intubated) Exclusion Criteria: 1. Greater than 96 h since hospitalization at the time of enrollment 2. Greater than 48 h since intubation at the time of enrollment 3. A previous MSC infusion not related to this trial 4. History of Pulmonary Hypertension (WHO Class III/IV) 5. History of left atrial hypertension or decompensated left heart failure. 6. Pregnant or lactating patient 7. Unstable arrhythmia 8. Patients currently receiving immunosuppression with exception of up to 10 mg Prednisone equivalents daily 9. Patients currently receiving chronic dialysis 10. Patients currently receiving Extracorporeal Membrane Oxygenation (ECMO) 11. Presence of any active malignancy (except non-melanoma skin cancer) 12. Moderate to severe liver disease (AST and ALT \>5 X ULN) 13. Severe chronic respiratory disease with a PaCO2 \> 50 mm Hg or the use of home oxygen at rest 14. Septic Shock (with \>1 vasopressor) 15. Multi-organ failure 16. Not expected to survive \> 48 hours