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Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC
Sponsor: Fondazione del Piemonte per l'Oncologia
Summary
This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.
Official title: A Multicenter, Randomized, Parallel-Group Trial Evaluating Progel Platinum Added to Mechanical Stapling Versus Mechanical Stapling Alone in Patients Undergoing VATS Upper or Lower Lobectomy for Non-Small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2026-02-27
Completion Date
2027-12-31
Last Updated
2026-03-18
Healthy Volunteers
No
Interventions
Progel Platinum
Progel Platinum surgical sealant applied to the completed fissure line after stapled fissure completion during VATS upper or lower lobectomy
Mechanical Stapling
Standard mechanical stapling used for fissure completion during VATS upper or lower lobectomy.
Locations (6)
Unità di Chirurgia Toracica Oncologica
Candiolo, Torino, Italy
Ospedale centrale di Bolzano, Chirurgia Toracica e Vascolare
Bolzano, Italy
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Italy
Irccs Ismett
Palermo, Italy
Azienda Ospedaliera-Universitaria Pisana
Pisa, Italy