Clinical Research Directory
Browse clinical research sites, groups, and studies.
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Sponsor: Peking University First Hospital
Summary
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain. Currently, there is a lack of clinical strategies to safely and effectively manage postoperative pain in children undergoing adenoid and tonsil surgery. Dexmedetomidine and esketamine can achieve appropriate sedation levels and alleviate postoperative pain when used in children. Both drugs can be administered intranasally, and their pharmacological effects complement each other, reducing side effects. This study aims to investigate whether intranasal administration of dexmedetomidine-esketamine combination can improve postoperative analgesia in children undergoing adenoid and tonsil surgery.
Official title: Impact of Intranasal Dexmedetomidine-esketamine Administration on Postoperative Pain in Pediatric Patients Undergoing Adenotonsillectomy: a Randomized, Placebo-controlled Trial
Key Details
Gender
All
Age Range
3 Years - 7 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2026-04-07
Completion Date
2027-02
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
Intranasal dexmedetomidine-esketamine
A mixture of dexmedetomidine-esketamine combination will administered intranasally after anesthesia induction.
Intranasal placebo (normal saline)
Placebo (normal saline) will administered intranasally after anesthesia induction.
Locations (1)
Peking University First Hospital
Beijing, Beijing Municipality, China