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Berberine Supplementation, Sprint Interval Training, and Immune Function Study
Sponsor: University of Northern Colorado
Summary
The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are: * Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality? * Does short-term berberine use or sprint training improve measures of anaerobic power generation? * Does short-term berberine use or sprint training improve circulating biomarkers of inflammation? * Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?
Official title: Effects of 2-Weeks of Berberine and Sprint Interval Training on Wellbeing, Anaerobic Power, and Monocyte Number and Function
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-01-01
Completion Date
2026-06-01
Last Updated
2026-05-07
Healthy Volunteers
Yes
Interventions
Berberine
Consumption of a commercially-available Berberine supplement at a dosage of 500mg, Three times per day with meals, for a total dosage of 1500mg/day.
Placebo
Consumption of placebo capsules composed of rice flour at a dosing of 3 capsules per day with meals.
Sprint Interval Training
Multiple sets of maximal effort 30 second sprints, inter spaced with 4 minutes of rest/active recovery, on the cycle ergometer over the course of 6 sessions during the 2-Week intervention. Resistance for each set is calculated at 7.5% of the body mass of the participant. Sets for each session are as follows: (1) 4 Sets, (2) 5 Sets, (3) 6 Sets, (4) 6 Sets, (5) 7 Sets, (6) 4 Sets.
Locations (1)
University of Northern Colorado
Greeley, Colorado, United States