Clinical Research Directory
Browse clinical research sites, groups, and studies.
Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16)
Sponsor: Beijing Biotech
Summary
This Phase 1/2 study evaluates the safety, tolerability, and preliminary anti-tumor activity of dual-targeting chimeric antigen receptor natural killer (CAR-NK) cells in participants with recurrent or refractory epithelial ovarian, primary peritoneal, or fallopian tube cancer. At screening, each participant's tumor is assessed for expression of Mesothelin (MSLN), Folate Receptor alpha (FRalpha/FOLR1), and MUC16 (CA 125). Participants are assigned to the dual-target CAR-NK product that best matches their tumor antigen profile to reduce the risk of antigen escape.
Official title: A Phase 1/2, Open-Label, Biomarker-Assigned Study of Dual-Targeting CAR-NK Cells Directed Against Mesothelin (MSLN), Folate Receptor Alpha (FRα/FOLR1), and/or MUC16 (CA125) in Patients With Recurrent or Refractory High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
Key Details
Gender
FEMALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-02-04
Completion Date
2028-05-17
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
Dual-target CAR-NK cell product
(Arm-specific)
Lymphodepleting chemotherapy
(cyclophosphamide and fludarabine)
Standard supportive care
antimicrobial prophylaxis per institutional practice
Locations (1)
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China