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RECRUITING
NCT07480954
PHASE1/PHASE2

Dual-Targeting CAR-NK Cells for Recurrent Ovarian Cancer (MSLN, FRα, MUC16)

Sponsor: Beijing Biotech

View on ClinicalTrials.gov

Summary

This Phase 1/2 study evaluates the safety, tolerability, and preliminary anti-tumor activity of dual-targeting chimeric antigen receptor natural killer (CAR-NK) cells in participants with recurrent or refractory epithelial ovarian, primary peritoneal, or fallopian tube cancer. At screening, each participant's tumor is assessed for expression of Mesothelin (MSLN), Folate Receptor alpha (FRalpha/FOLR1), and MUC16 (CA 125). Participants are assigned to the dual-target CAR-NK product that best matches their tumor antigen profile to reduce the risk of antigen escape.

Official title: A Phase 1/2, Open-Label, Biomarker-Assigned Study of Dual-Targeting CAR-NK Cells Directed Against Mesothelin (MSLN), Folate Receptor Alpha (FRα/FOLR1), and/or MUC16 (CA125) in Patients With Recurrent or Refractory High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2026-02-04

Completion Date

2028-05-17

Last Updated

2026-03-18

Healthy Volunteers

No

Interventions

BIOLOGICAL

Dual-target CAR-NK cell product

(Arm-specific)

DRUG

Lymphodepleting chemotherapy

(cyclophosphamide and fludarabine)

OTHER

Standard supportive care

antimicrobial prophylaxis per institutional practice

Locations (1)

Peking University Shenzhen Hospital

Shenzhen, Guangdong, China