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NOT YET RECRUITING
NCT07481630
PHASE3

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Official title: Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 5)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

400

Start Date

2026-04-13

Completion Date

2028-07-17

Last Updated

2026-03-19

Healthy Volunteers

No

Interventions

DRUG

NNC0487-0111

NNC0487-0111 dose level 1 and dose level 2 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

DRUG

Placebo (matched to NNC0487-0111 )

Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Locations (76)

Arizona Research Center, Inc.

Phoenix, Arizona, United States

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Chase Medical Research LLC

Hamden, Connecticut, United States

Chase Medical Research LLC

Waterbury, Connecticut, United States

Zenith clinical research

Hollywood, Florida, United States

CNS Healthcare

Jacksonville, Florida, United States

Angels Clinical Research Institute

Miami Lakes, Florida, United States

Hope Clin Res & Wellness

Conyers, Georgia, United States

CenExel iResearch, LLC

Decatur, Georgia, United States

Elite Clinical Trials

Blackfoot, Idaho, United States

MedVadis Research Watertown

Waltham, Massachusetts, United States

Jubilee Clinical Research, Inc.

Las Vegas, Nevada, United States

Great Lakes Medical Research

Westfield, New York, United States

Accellacare Wilmington

Wilmington, North Carolina, United States

Coastal Carolina Res Ctr

North Charleston, South Carolina, United States

VIP Trials_San Antonio

San Antonio, Texas, United States

Charlottesville Med Research

Charlottesville, Virginia, United States

Health Res of Hampton Roads

Newport News, Virginia, United States

Northwest Clinical Research Center

Bellevue, Washington, United States

Emeritus Research Sydney

Botany, New South Wales, Australia

Momentum Clinical Research Darlinghurst

Darlinghurst, New South Wales, Australia

Kolling Institute

St Leonards, New South Wales, Australia

Heart of Australia

Chelmer, Queensland, Australia

Coastal Digestive Health

Maroochydore, Queensland, Australia

UMHAT Sveti Georgi EAD, Plovdiv

Plovdiv, Bulgaria

MC Dr. Atanasov EOOD

Sofia, Bulgaria

MC Excelsior OOD

Sofia, Bulgaria

UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology

Sofia, Bulgaria

MMA MHAT - Sofia, Rheumatology clinic

Sofia, Bulgaria

UMHAT Sveti Ivan Rilski EAD, Rheumatology

Sofia, Bulgaria

Laser Rejuvenation Clinics Inc.

Calgary, Alberta, Canada

Dawson Clinical Research

Guelph, Ontario, Canada

Hamilton Medical Rsrch Grp

Hamilton, Ontario, Canada

Centre de Recherche Musculo

Trois-Rivières, Quebec, Canada

Alpha Recherche Clinique - Lebourgneuf

Québec, Canada

Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme

Aarhus N, Denmark

Frederiksberg Hospital - Parker Institutet (Artrose)

Frederiksberg, Denmark

Sanos Clinic - Herlev

Herlev, Denmark

University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine

Chaïdári, Attica, Greece

Laiko General Hospital Of Athens - 1st department of Internal Medicine

Athens, Greece

Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases

Athens, Greece

General Hospital Of Athens Alexandra - Clinical Therapeutics

Athens, Greece

Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

Marousi, Greece

NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

Thessaloniki, Greece

Thermi Clinic S.A. - Diabetes and Internal Medicine Department

Thessaloniki, Greece

AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Medicina Interna e Nutrizione Clinica

Naples, Campania, Italy

Ospedale Civile di Baggiovara - UOC Endocrinologia

Modena, Emilia-Romagna, Italy

Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo

Udine, Friuli Venezia Giulia, Italy

Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

Rome, Lazio, Italy

Auxologico San Luca - Endocrinologia e Malattie del Metabolismo

Milan, Lombardy, Italy

Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica

San Donato Milanese, Lombardy, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia

Verona, Veneto, Italy

"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

Bialystok, Podlaskie Voivodeship, Poland

ClinicMed Daniluk, Nowak Spółka Komandytowa

Bialystok, Poland

Centrum Medyczne Intercor Sp. z o.o.

Bydgoszcz, Poland

CenterMed Kraków Sp. z o.o.

Krakow, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

Krakow, Poland

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

Warsaw, Poland

Instituto Medico Quirurgico San Rafael

A Coruña, Spain

Hospital Germans Trias i Pujol

Badalona, Spain

Hospital Naval Ferrol

Ferrol, Spain

Centro Especialidades Hermanos Sangro

Madrid, Spain

Hospital Quirónsalud Málaga

Málaga, Spain

Hospital Infanta Sofía

San Sebastián de Los Reyes (Madrid), Spain

Hospital Universitario Marqués de Valdecilla

Santander, Spain

Hospital HM La Esperanza

Santiago de Compostela, Spain

Clínica Nuevas Tecnologías en Diabetes y Endocrinología

Seville, Spain

H. Infanta Luisa_Endocrino y Obesidad

Seville, Spain

Hospital General de Valencia

Valencia, Spain

Ankara Üniversitesi Sağlık Uygulama ve Araştırma Hastaneleri- Fiziksel Tıp ve Rehabilitasyon

Altındağ/Ankara, Turkey (Türkiye)

İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

Bahçelievler/İstanbul, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon

Çankaya/Ankara, Turkey (Türkiye)

Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi-Fiziksel Tıp ve Rehabilitasyon

Kepez/Çanakkale Merkez/Çanakkale, Turkey (Türkiye)

İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi-Fiziksel Tıp ve Rehabilitasyon

Merkez/Battalgazi/Malatya, Turkey (Türkiye)

Karadeniz Teknik Üniversitesi Farabi Hastanesi- Fiziksel Tıp ve Rehabilitasyon

Trabzon Merkez/Ortahisar/Trabzon, Turkey (Türkiye)

Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

Yuregir/Adana, Turkey (Türkiye)