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A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Sponsor: Novo Nordisk A/S
Summary
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Official title: Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 5)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2026-04-13
Completion Date
2028-07-17
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
NNC0487-0111
NNC0487-0111 dose level 1 and dose level 2 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Placebo (matched to NNC0487-0111 )
Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.
Locations (76)
Arizona Research Center, Inc.
Phoenix, Arizona, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Chase Medical Research LLC
Hamden, Connecticut, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Zenith clinical research
Hollywood, Florida, United States
CNS Healthcare
Jacksonville, Florida, United States
Angels Clinical Research Institute
Miami Lakes, Florida, United States
Hope Clin Res & Wellness
Conyers, Georgia, United States
CenExel iResearch, LLC
Decatur, Georgia, United States
Elite Clinical Trials
Blackfoot, Idaho, United States
MedVadis Research Watertown
Waltham, Massachusetts, United States
Jubilee Clinical Research, Inc.
Las Vegas, Nevada, United States
Great Lakes Medical Research
Westfield, New York, United States
Accellacare Wilmington
Wilmington, North Carolina, United States
Coastal Carolina Res Ctr
North Charleston, South Carolina, United States
VIP Trials_San Antonio
San Antonio, Texas, United States
Charlottesville Med Research
Charlottesville, Virginia, United States
Health Res of Hampton Roads
Newport News, Virginia, United States
Northwest Clinical Research Center
Bellevue, Washington, United States
Emeritus Research Sydney
Botany, New South Wales, Australia
Momentum Clinical Research Darlinghurst
Darlinghurst, New South Wales, Australia
Kolling Institute
St Leonards, New South Wales, Australia
Heart of Australia
Chelmer, Queensland, Australia
Coastal Digestive Health
Maroochydore, Queensland, Australia
UMHAT Sveti Georgi EAD, Plovdiv
Plovdiv, Bulgaria
MC Dr. Atanasov EOOD
Sofia, Bulgaria
MC Excelsior OOD
Sofia, Bulgaria
UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology
Sofia, Bulgaria
MMA MHAT - Sofia, Rheumatology clinic
Sofia, Bulgaria
UMHAT Sveti Ivan Rilski EAD, Rheumatology
Sofia, Bulgaria
Laser Rejuvenation Clinics Inc.
Calgary, Alberta, Canada
Dawson Clinical Research
Guelph, Ontario, Canada
Hamilton Medical Rsrch Grp
Hamilton, Ontario, Canada
Centre de Recherche Musculo
Trois-Rivières, Quebec, Canada
Alpha Recherche Clinique - Lebourgneuf
Québec, Canada
Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme
Aarhus N, Denmark
Frederiksberg Hospital - Parker Institutet (Artrose)
Frederiksberg, Denmark
Sanos Clinic - Herlev
Herlev, Denmark
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine
Chaïdári, Attica, Greece
Laiko General Hospital Of Athens - 1st department of Internal Medicine
Athens, Greece
Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases
Athens, Greece
General Hospital Of Athens Alexandra - Clinical Therapeutics
Athens, Greece
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
Marousi, Greece
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
Thessaloniki, Greece
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
Thessaloniki, Greece
AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Medicina Interna e Nutrizione Clinica
Naples, Campania, Italy
Ospedale Civile di Baggiovara - UOC Endocrinologia
Modena, Emilia-Romagna, Italy
Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo
Udine, Friuli Venezia Giulia, Italy
Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia
Rome, Lazio, Italy
Auxologico San Luca - Endocrinologia e Malattie del Metabolismo
Milan, Lombardy, Italy
Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica
San Donato Milanese, Lombardy, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia
Verona, Veneto, Italy
"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
Bialystok, Podlaskie Voivodeship, Poland
ClinicMed Daniluk, Nowak Spółka Komandytowa
Bialystok, Poland
Centrum Medyczne Intercor Sp. z o.o.
Bydgoszcz, Poland
CenterMed Kraków Sp. z o.o.
Krakow, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
Krakow, Poland
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
Warsaw, Poland
Instituto Medico Quirurgico San Rafael
A Coruña, Spain
Hospital Germans Trias i Pujol
Badalona, Spain
Hospital Naval Ferrol
Ferrol, Spain
Centro Especialidades Hermanos Sangro
Madrid, Spain
Hospital Quirónsalud Málaga
Málaga, Spain
Hospital Infanta Sofía
San Sebastián de Los Reyes (Madrid), Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital HM La Esperanza
Santiago de Compostela, Spain
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
Seville, Spain
H. Infanta Luisa_Endocrino y Obesidad
Seville, Spain
Hospital General de Valencia
Valencia, Spain
Ankara Üniversitesi Sağlık Uygulama ve Araştırma Hastaneleri- Fiziksel Tıp ve Rehabilitasyon
Altındağ/Ankara, Turkey (Türkiye)
İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
Bahçelievler/İstanbul, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon
Çankaya/Ankara, Turkey (Türkiye)
Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi-Fiziksel Tıp ve Rehabilitasyon
Kepez/Çanakkale Merkez/Çanakkale, Turkey (Türkiye)
İnönü Üniversitesi Turgut Özal Tıp Merkezi Hastanesi-Fiziksel Tıp ve Rehabilitasyon
Merkez/Battalgazi/Malatya, Turkey (Türkiye)
Karadeniz Teknik Üniversitesi Farabi Hastanesi- Fiziksel Tıp ve Rehabilitasyon
Trabzon Merkez/Ortahisar/Trabzon, Turkey (Türkiye)
Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon
Yuregir/Adana, Turkey (Türkiye)