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Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
Sponsor: University Hospital, Motol
Summary
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic. Participants are recruited through schools and complete a web-based questionnaire assessing reflux-related symptoms. Children reporting pyrosis or regurgitation undergo a stepwise diagnostic evaluation that includes a standardized proton pump inhibitor (PPI) trial, upper endoscopy when indicated, and 24-hour pH-impedance monitoring for those with inconclusive findings. These procedures allow classification into confirmed GERD, reflux hypersensitivity, or functional pyrosis. All children undergoing diagnostic testing complete a validated quality-of-life questionnaire. The study will provide population-based prevalence estimates and evaluate symptom burden and potential risk factors associated with pediatric GERD.
Official title: Prevalence of Symptomatic Gastroesophageal Reflux Disease in Children in the Czech Republic
Key Details
Gender
All
Age Range
8 Years - 13 Years
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2025-12-20
Completion Date
2028-12-30
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Locations (1)
Motol University Hospital
Prague, Czechia