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Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Sponsor: Aristotle University Of Thessaloniki
Summary
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart. Early detection of organ dysfunction is important for identifying children at increased risk for complications. This observational cross-sectional study aims to evaluate biomarkers of acute organ injury and associated clinical and echocardiographic parameters in children with newly diagnosed T1DM presenting with DKA, compared with children with newly diagnosed T1DM without DKA and healthy controls. Biomarkers including KIM-1, NGAL, high-sensitivity troponin, NT-proBNP, interleukin-6, and C-reactive protein will be measured during hospital admission and within the first 24-48 hours of hospitalization.
Official title: Evaluation of Biomarkers and Clinical Parameters of Acute Organ Injury in Children With Newly Diagnosed Type 1 Diabetes: The Effect of Diabetic Ketoacidosis
Key Details
Gender
All
Age Range
2 Years - 16 Years
Study Type
OBSERVATIONAL
Enrollment
45
Start Date
2025-06-13
Completion Date
2030-03
Last Updated
2026-03-19
Healthy Volunteers
Yes
Interventions
Biomarker and Echocardiographic Assessment
Blood and urine samples and echocardiographic evaluation performed as part of the clinical assessment of children with newly diagnosed type 1 diabetes.
Locations (1)
Hippokration General Hospital of Thessaloniki
Thessaloniki, Central Makedonia, Greece