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Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
Sponsor: Henan Provincial People's Hospital
Summary
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use inhibitors for pain control of phenotype conversion. The significance is to accurately guide the perioperative analgesia of oxycodone in elderly patients, and to more effectively avoid toxicity and adverse reactions.
Official title: Effect of CYP2D6 on Perioperative Analgesia of Oxycodone in Elderly Patients
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-01-01
Completion Date
2025-09-30
Last Updated
2026-05-12
Healthy Volunteers
Yes
Conditions
Interventions
oxycodone
All patients undergoing thoracic surgery were given oxycodone 0.07 mg / kg for bridging analgesia 20 minutes before the end of surgery. Patient-controlled intravenous analgesia pump was connected within 5 minutes after operation ( formula : oxycodone 0.5 mg / kg + dexmedetomidine 3 μg / kg + tropisetron 0.3 mg / kg = 150 ml ).
Locations (1)
Henan Provincial People's Hospital
Zhengzhou, Henan, China