Clinical Research Directory

Molecular Profiling of MRI-PSMA PET Discordance in Prostate Cancer

Sponsor: IRCCS San Raffaele

Summary

MRI and PSMA-PET are highly sensitive imaging tools for prostate cancer, yet they often detect different lesions. These discordant findings pose clinical uncertainty because their biological significance is unclear. This project aims to molecularly characterize MRI-PSMA PET discordant lesions using high-quality biobanked samples from patients enrolled in an institutional study (NCT06187870). By integrating imaging and molecular data, the study will clarify whether these lesions represent indolent disease, aggressive subclones, or biologically distinct entities, and will assess their clinical implications.

Official title: Molecular Profiling of Prostate Cancer Lesions With MRI-PSMA PET Discordance

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