Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

RECRUITING

NCT07486960

PHASE2

Sponsor: Merck Sharp & Dohme LLC

Summary

Researchers are looking for new ways to treat Psoriatic Arthritis (PsA). This study will help find out if a study medicine called tulisokibart (MK-7240) can treat symptoms of active PsA. This study assesses the efficacy, safety, and tolerability of tulisokibart in adult participants with active PsA. In this study, researchers will look at different doses of tulisokibart. Researchers want to learn if at least one of the study doses of tulisokibart works better than a placebo to lessen PsA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

Official title: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Psoriatic Arthritis.

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

140

Start Date

2026-04-20

Completion Date

2030-01-11

Last Updated

2026-07-06

Healthy Volunteers

No

Conditions

Psoriatic Arthritis

Interventions

DRUG

Tulisokibart

Subcutaneous administration

DRUG

Placebo

Subcutaneous administration

Locations (46)

Arizona Arthritis & Rheumatology Associates, P.C. ( Site 5117)

Sun City, Arizona, United States

Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 5120)

Tucson, Arizona, United States

Medvin Clinical Research - Riverside ( Site 5115)

Riverside, California, United States

Cohen Medical Centers ( Site 5111)

Thousand Oaks, California, United States

Medvin Clinical Research - Tujunga ( Site 5113)

Tujunga, California, United States

Arthritis and Rheumatic Disease Specialties ( Site 5105)

Aventura, Florida, United States

International Center for Research ( Site 5124)

Tampa, Florida, United States

St. Luke's Clinic - Rheumatology - Boise ( Site 5109)

Boise, Idaho, United States

Arthritis and Rheumatism Associates - Rockville ( Site 5127)

Rockville, Maryland, United States

Kansas City Physician Partners ( Site 5119)

Kansas City, Missouri, United States

Physician Research Collaboration, LLC ( Site 5102)

Lincoln, Nebraska, United States

Joint and Muscle Research Institute ( Site 5108)

Charlotte, North Carolina, United States

Altoona Center for Clinical Research ( Site 5110)

Duncansville, Pennsylvania, United States

Hospital of the University of Pennsylvania ( Site 5134)

Philadelphia, Pennsylvania, United States

Articularis Healthcare Group dba: Low Country Rheumatology ( Site 5128)

Summerville, South Carolina, United States

Greater Houston Rheumatology ( Site 5103)

Houston, Texas, United States

Centre Rhumatologie De L'Est ( Site 5201)

Rimouski, Quebec, Canada

Centre de Recherche Musculo-Squelettique ( Site 5202)

Trois-Rivières, Quebec, Canada

Centro de Estudios GyC ( Site 8206)