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RECRUITING
NCT07488078
PHASE1

Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery

Sponsor: King Edward Medical University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn whether giving less intravenous (IV) fluid (restrictive administration) after surgery is as effective as giving more IV fluid (liberal administration) in maintaining body stability (homeostasis) among adults undergoing laparoscopic gallbladder removal (cholecystectomy). The main questions it aims to answer are: Does restrictive IV fluid administration maintain stable blood pressure, heart rate, and urine output after laparoscopic cholecystectomy? Are there any differences in postoperative recovery or complications between restrictive and liberal fluid regimens? Researchers will compare patients receiving liberal IV fluid administration with those receiving restrictive IV fluid administration to see if both methods maintain similar postoperative homeostasis and recovery outcomes. Participants will: Be adults aged 18-60 years (ASA class I-II) undergoing elective laparoscopic cholecystectomy. Be randomly assigned to one of two groups: Group A: Liberal IV fluid administration for 6 hours after surgery. Group B: Restrictive IV fluid administration for 6 hours after surgery. Have their vital signs (pulse, blood pressure, mean arterial pressure) and urine output recorded at multiple time points after surgery (immediate, 3, 6, 12, and 24 hours).

Official title: Effect of Liberal Versus Restrictive Intravenous Fluid Administration on Postoperative Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

380

Start Date

2025-12-01

Completion Date

2026-07-28

Last Updated

2026-03-23

Healthy Volunteers

No

Interventions

DRUG

Lactated Ringer 500ml

500ml ringer lactate perioperatively given in laparoscopic cholecystectomy patients as compared to traditional 1000ml fluid

DRUG

Lactated Ringer 1000ml

1000ml iv fluid given perioperatively in laparoscopic cholecystectomy

Locations (1)

King Edward Medical University Lahore / Mayo Hospital Lahore

Lahore, Punjab Province, Pakistan