Clinical Research Directory

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Diagnosis of WHO grade II-III glioma involving eloquent language cortex * Scheduled for surgical resection * MRI-compatible * Ability to perform the simple language tasks required for fMRI and neurofeedback * Residence within 2 hours of Yale MRRC and ability and willingness to make multiple visits for study participation Exclusion Criteria: * Severe baseline aphasia precluding task performance * Contraindications to MRI * Significant cognitive/psychiatric comorbidity limiting compliance * Concurrent enrollment in other interventional trials * Claustrophobia of a degree that they cannot comfortably be scanned * Inability or unwillingness to understand or follow the instructions * Pregnancy or possible pregnancy