Clinical Research Directory

Inclusion Criteria: 1. Male or female participants must be ≥ 18 years old. 2. Mean seated SBP ≥ 140 mmHg at Screening and at Baseline.. 3. Fulfil at least 1 of the following 2 criteria: * Uncontrolled Hypertension (uHTN) subpopulation: have a stable regimen (≥ 4 weeks) of 2 antihypertensive medications, from different therapeutic classes (at least one must be a diuretic), at maximum tolerated dose in the judgement of the Investigator. * Resistant Hypertension (rHTN) subpopulation: have a stable regimen (≥ 4 weeks) of ≥ 3 antihypertensive medications, from different therapeutic classes (at least one must be a diuretic), at maximum tolerated dose in the judgement of the Investigator. Exclusion Criteria: 1. Mean seated systolic blood pressure (SBP)≥ 180 mmHg. 2. Mean seated diastolic blood pressure (DBP)≥ 110 mmHg. 3. Estimated glomerular filtration rate \< 45 mL/min/1.73m2. 4. Serum potassium (K+) level \<3.5 and ≥ 5.0 mmol/L. 5. Has the following known secondary causes of hypertension: renal artery stenosis, uncontrolled or untreated hyperthyroidism, uncontrolled or untreated hypothyroidism, pheochromocytoma, Cushing's syndrome, aortic coarctation. 6. NYHA functional heart failure class IV at Screening.