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Non-apnea Electrical Impedance Tomography for Bedside Ventilation-Perfusion Assessment: a Prospective Cross-over Validation Study
Sponsor: Ruijin Hospital
Summary
Title: Validating the Accuracy of Lung Blood Flow Monitoring Without Breath-Holding Under Spontaneous Breathing Support Purpose: The purpose of this study is to evaluate the accuracy of a new Electrical Impedance Tomography (EIT) technique that measures lung blood flow (perfusion) without requiring patients to hold their breath. We aim to determine if this "non-apnea" method provides results consistent with the current clinical gold standard (the "pause" method). Background: EIT is a non-invasive bedside tool used to monitor lung function. The traditional method for measuring lung blood flow requires patients to hold their breath for 5-8 seconds during a saline injection to avoid interference from breathing. However, many patients-especially those using a nasal cannula, high-flow nasal oxygen (HFNO), or pressure support ventilation (PSV)-must maintain continuous spontaneous breathing and find it difficult or unsafe to hold their breath. If a "non-apnea" method is proven accurate, it will make monitoring safer and easier for these patients. What the Study Involves: The study includes stable adult patients who are breathing spontaneously. Each patient undergoes two measurements in a randomized order: Standard Reference (Pause Method): Measurement taken during a brief, guided breath-hold. Test Method (Non-Apnea Method): Measurement taken during normal, uninterrupted breathing while receiving respiratory support (Nasal Cannula, HFNO, or PSV). Expected Significance: By comparing the lung images and ventilation/perfusion (V/Q) data from both methods, this study seeks to validate the reliability and precision of the non-apnea approach. This would allow clinicians to assess lung health in spontaneously breathing patients without interrupting their natural breathing rhythm.
Official title: Non-apnea Saline-contrast EIT for Lung Perfusion Imaging in Spontaneously Breathing Patients: A Prospective Cross-over Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-03-19
Completion Date
2026-04-13
Last Updated
2026-04-23
Healthy Volunteers
No
Interventions
Saline-contrast EIT with a non-apnea algorithm
Participants receive a central venous bolus injection of 10 mL 10% NaCl. Lung perfusion is then assessed using Electrical Impedance Tomography (EIT). The intervention evaluates two acquisition conditions: one during a brief respiratory pause (reference) and one during uninterrupted spontaneous breathing (test).
Locations (1)
Department of Critical Care Medicine，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China