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Effect of Ambient Temperature on Blood Glucose and Insulin Absorption in Adults With Type 1 Diabetes
Sponsor: Institut de Recherches Cliniques de Montreal
Summary
The goal of this clinical trial is to learn how different temperatures affect blood sugar levels in adults with type 1 diabetes. Climate change is causing more extreme hot and cold weather, and people with type 1 diabetes may be at higher risk during these temperature changes. The main questions it aims to answer are: * Do different temperatures (cold, normal, or hot) change blood sugar levels in people with type 1 diabetes? * How does temperature affect insulin absorption in the body? Researchers will compare three different temperature conditions to see how each affects blood sugar levels and insulin in the body. Participants will: * Complete a screening visit with body measurements and questionnaires * Attend 3 separate study visits, each in a different temperature setting: * Cold room (10°C/50°F) * Normal room temperature (23°C/73°F) * Hot and humid room (36°C/97°F with 65% humidity) * Sit for 2 hours in each temperature condition while researchers monitor their blood sugar, heart rate, and body temperature * Wear a continuous glucose monitor for 48-72 hours before each visit * Keep a diary of food, sleep, and activity for 24 hours before and after each visit Each temperature visit is separated by at least 3 days. The study helps researchers understand if people with type 1 diabetes need special guidance for managing their blood sugar during extreme weather.
Official title: Effect of Ambient Temperature on Insulin Absorption and Change in Blood Glucose Levels in Individuals With Type 1 Diabetes
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-03
Completion Date
2027-07
Last Updated
2026-03-24
Healthy Volunteers
No
Conditions
Interventions
Environmental Temperature Exposure
Systematic exposure to controlled temperature and humidity conditions in a specialized environmental chamber. Each exposure lasts 120 minutes with participants remaining seated throughout. All exposures include standardized pre-exposure preparation (60-minute baseline period at room temperature), continuous physiological monitoring, standardized clothing, and identical blood sampling schedules. Safety protocols include continuous staff supervision, predetermined stopping criteria for extreme body temperatures or blood pressure changes, and immediate availability of warming/cooling interventions and hypoglycemia treatment protocols.
Locations (1)
Institut de recherches cliniques de Montréal
Montreal, Quebec, Canada