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Efficacy of Using Knotless Barbed Suture vs N-Butyl Cyanoacrylate Glue Tissue Adhesive for Closure of Intraoral Surgical Incisions
Sponsor: Future University in Egypt
Summary
This clinical study aims to compare the efficacy of knotless barbed sutures versus N-butyl cyanoacrylate glue tissue adhesive for the closure of intra-oral surgical incisions, with traditional PGA vicryl sutures as a control group. The study evaluates three primary outcomes: the time required for incision closure, postoperative pain levels using the Visual Analog Scale (VAS) score, and the soft tissue healing progress using Landry's wound healing index. Secondary outcomes will include the assessment of postoperative edema and other clinical healing parameters. The goal is to determine which closure technique provides superior surgical efficiency, less patient discomfort, and better wound healing in oral and maxillofacial procedures.
Official title: Efficacy of Using Knotless Barbed Suture vs N-Butyl Cyanoacrylate Glue Tissue Adhesive for Closure of Intraoral Surgical Incisions (Randomized Controlled Clinical Study).
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-06-16
Completion Date
2026-05
Last Updated
2026-03-25
Healthy Volunteers
No
Interventions
PDO Knotless Barbed Suture
A self-securing monofilament suture with microscopic barbs that eliminate the need for surgical knots during wound closure.
N-Butyl Cyanoacrylate Glue (PERIACRYL)
A bacteriostatic tissue adhesive applied to approximated wound edges to provide secure closure and a microbial barrier.
3/0 Resorbable PGA Suture
Conventional polyglycolic acid (PGA) resorbable sutures used with standard surgical knot-tying techniques.
Locations (1)
Faculty of Oral and Dental Medicine, Future University in Egypt
New Cairo, Cairo Governorate, Egypt