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Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
Sponsor: University of Edinburgh
Summary
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome. Furthermore, the investigators will be assessing the effects different cardiac medications have on these physiological mechanisms. This will be achieved by performing cardiac MRI scans using a special dye called manganese. Manganese uptake in the heart is altered in patients with takotsubo cardiomyopathy. The investigators will study the effects that different cardiac medications have on manganese uptake.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-08-08
Completion Date
2028-08-09
Last Updated
2026-03-24
Healthy Volunteers
Yes
Conditions
Interventions
Bisoprolol
Participants will be randomised to receive Bisoprolol medication.
Valsartan
Participants will be randomised to receive Valsartan medication.
sacubitril/ valsartan
Participants will be randomised to receive Sacubitril/Valsartan medication first.
Dapagliflozin (10mg Tab)
Participants will be randomised to receive Dapaglifozin medication first.
No medications
Participants will be randomised to receive no study medication.
Locations (1)
University of Edinburgh
Edinburgh, United Kingdom