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Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
Sponsor: University Hospital, Basel, Switzerland
Summary
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect). In the study, moderate pain will be artificially created in healthy participants using repeated small electrical pulses applied under the skin. At the same time, participants will take MDMA or a placebo by mouth. This allows researchers to compare how MDMA affects the artificially created pain. A total of 20 healthy volunteers will take part in this study.
Official title: Acute Analgesic Effects of 3,4-methylenedioxymethamphetamine (MDMA) on Experimentally Induced Acute Nociceptive Pain, Hyperalgesia and Allodynia in Healthy Participants (MDPS-study)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-03-09
Completion Date
2027-04-09
Last Updated
2026-03-27
Healthy Volunteers
Yes
Conditions
Interventions
MDMA 25 mg
oral administration
MDMA 75 mg
oral administration
MDMA 125 mg
oral administration
Placebo
oral administration
Locations (1)
Clinical Pharmacology & Toxicology, University Hospital Basel
Basel, Switzerland