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RECRUITING
NCT07494214
PHASE1

Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants

Sponsor: University Hospital, Basel, Switzerland

View on ClinicalTrials.gov

Summary

This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect). In the study, moderate pain will be artificially created in healthy participants using repeated small electrical pulses applied under the skin. At the same time, participants will take MDMA or a placebo by mouth. This allows researchers to compare how MDMA affects the artificially created pain. A total of 20 healthy volunteers will take part in this study.

Official title: Acute Analgesic Effects of 3,4-methylenedioxymethamphetamine (MDMA) on Experimentally Induced Acute Nociceptive Pain, Hyperalgesia and Allodynia in Healthy Participants (MDPS-study)

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2026-03-09

Completion Date

2027-04-09

Last Updated

2026-03-27

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

MDMA 25 mg

oral administration

DRUG

MDMA 75 mg

oral administration

DRUG

MDMA 125 mg

oral administration

DRUG

Placebo

oral administration

Locations (1)

Clinical Pharmacology & Toxicology, University Hospital Basel

Basel, Switzerland