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Exploring the Physiological Mechanisms of Austism Through Organoids
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting approximately 1% of the population, characterized by difficulties with social interaction and communication. Studies have identified more than 200 genes linked to ASD, particularly those involved in chromatin remodeling and synaptic neuronal connectivity (CHD8, SCN2A, NLGN3-4X, SHANK1-3). The goal of the project is to decipher the biological mechanisms underlying ASD in order to develop therapeutic strategies, using innovative preclinical models such as organoids.
Official title: Exploring the Physiologicla Mechainisms of Austism Through Organoids Derived Differentiated Cells of Individuals With Autism
Key Details
Gender
All
Age Range
2 Years - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2026-05-01
Completion Date
2028-05-01
Last Updated
2026-03-27
Healthy Volunteers
Yes
Conditions
Locations (1)
Robert Debré Hospital
Paris, France