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Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility
Sponsor: Tang-Du Hospital
Summary
The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility. Researchers will utilize an ultrasound multimodal system to systematically assess endometrial parameters, including thickness, morphology, peristalsis, and blood flow indices. The study aims to enroll approximately 300 infertile women aged 20 to 45 years. Participants will be observed and grouped based on whether they receive anticoagulant medications, such as aspirin or heparin sodium, as part of their standard clinical care. The study will track ultrasound-based receptivity indicators and follow up on pregnancy status and outcomes at 45 and 90 days of gestation. This study is purely observational, and all clinical treatment decisions are made independently of the study protocol.
Official title: Evaluation of the Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Patients With Infertility Using an Ultrasound Multimodal System
Key Details
Gender
FEMALE
Age Range
20 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-09-01
Completion Date
2027-12-31
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
Routine Anticoagulant Therapy (Aspirin or Heparin Sodium)
Patients receive low-dose aspirin or low molecular weight heparin (e.g., heparin sodium) purely as part of their standard clinical care. The decision to initiate, adjust, or terminate this therapy is made entirely by the attending physician based on clinical indications, strictly independent of this observational study protocol. This is tracked solely as an observational exposure.
Locations (1)
Tangdu Hospital, Air Force Medical University
Xi'an, Shaanxi, China