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Effect of GLP-1 Receptor Agonists on Body Composition in Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance
Sponsor: Hellenic Mediterranean University
Summary
This study investigates how weight-loss medications, specifically GLP-1 receptor agonists, affect body composition, with a special focus on preserving muscle mass in adults with obesity. While these medications are highly effective for weight loss, they can sometimes lead to an unwanted loss of valuable muscle mass (a condition that can lead to sarcopenia). To explore how to prevent this, researchers are conducting a 3- to 6-month randomized controlled trial involving adults aged 30 to 65 years with a BMI greater than 30 kg/m². Participants who are receiving GLP-1 medications will be randomly assigned to one of two groups: one group will receive the standard medication treatment alone, while the other group will receive the medication along with specific dietary guidance focused on increasing daily protein intake.
Official title: The Effect of GLP-1 Receptor Agonist-based Treatment on Body Composition and Muscle Mass in Adults With Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance
Key Details
Gender
All
Age Range
30 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2026-03-30
Completion Date
2029-01-30
Last Updated
2026-04-02
Healthy Volunteers
No
Conditions
Interventions
High Protein Dietary Intervention
Individualized dietary guidelines focusing on increased protein consumption to preserve muscle mass during weight loss.
Control (Standard Mediterranean Diet Counseling)
Standard nutritional counseling based on the Mediterranean diet pattern as part of usual clinical practice.
Locations (2)
1st Department of Internal Medicine, University General Hospital of Heraklion
Heraklion, Greece
Human Dietetics & Body Composition Laboratory, Department of Nutrition and Dietetics Sciences, Hellenic Mediterranean University
Heraklion, Greece