Clinical Research Directory

Immunological Phenotype of Desmoid-fibromatosis-affected Patients.

Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Summary

This observational study aims to characterize the molecular, phenotypic, and functional inflammatory and immunological profile of patients with sporadic desmoid-type fibromatosis undergoing either active surveillance or systemic therapy. The study includes analysis of the tumor immune microenvironment (TIME), circulating immune and inflammatory molecules, immune cell subsets, and circulating tumor DNA (ctDNA). The goal is to identify biomarkers associated with spontaneous or treatment-induced tumor regression and to evaluate potential correlations with specific ß-catenin mutations.

Official title: Immunological Profile of Patients With Desmoid-type Fibromatosis Under Active Surveillance.

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