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NOT YET RECRUITING
NCT07496567
PHASE2/PHASE3

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

Sponsor: EyeBiotech Ltd.

View on ClinicalTrials.gov

Summary

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)

Key Details

Gender

All

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

960

Start Date

2026-04-30

Completion Date

2028-07-31

Last Updated

2026-04-01

Healthy Volunteers

No

Interventions

DRUG

Tiespectus

Administered by intravitreal (IVT) injection

DRUG

Aflibercept

Administered by intravitreal (IVT) injection