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A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Sponsor: EyeBiotech Ltd.
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2026-04-15
Completion Date
2028-07-31
Last Updated
2026-05-04
Healthy Volunteers
No
Conditions
Interventions
Tiespectus
Administered by intravitreal (IVT) injection
Aflibercept
Administered by intravitreal (IVT) injection
Locations (9)
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, United States
University Retina & Macula Associates, P.C.
Lemont, Illinois, United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, United States
Retina Consultants of Minnesota
Edina, Minnesota, United States
Envision Ocular, LLC
Bloomfield, New Jersey, United States
Erie Retina Research
Erie, Pennsylvania, United States
Charleston Neuroscience Institute
Ladson, South Carolina, United States
Retina Consultants of Texas
Bellaire, Texas, United States
Pacific Northwest Retina
Bellevue, Washington, United States