Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Sponsor: EyeBiotech Ltd.
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2026-04-15
Completion Date
2028-07-31
Last Updated
2026-07-10
Healthy Volunteers
No
Conditions
Interventions
Tiespectus
Administered by intravitreal (IVT) injection
Aflibercept
Administered by intravitreal (IVT) injection
Locations (56)
Associated Retina Consultants - Gilbert
Gilbert, Arizona, United States
The Retina Partners
Encino, California, United States
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, United States
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, United States
RSC Research LLC
Denver, Colorado, United States
Retina Consultants of Southern Colorado
Pueblo, Colorado, United States
Connecticut Eye Consultants, P.C.
Danbury, Connecticut, United States
Retina Consultants, P.C.
Manchester, Connecticut, United States
Retina Group of New England
Waterford, Connecticut, United States
Retina Group of Florida
Fort Myers, Florida, United States
Florida Retina Institute
Orlando, Florida, United States
Retina Group of Florida (Site 065)
Sarasota, Florida, United States
Center for Retina and Macular Disease (Site 062)
Winter Haven, Florida, United States
Illinois Retina Associates
Joliet, Illinois, United States
University Retina & Macula Associates, P.C.
Lemont, Illinois, United States
Wolfe Eye Clinic
West Des Moines, Iowa, United States
Retina Associates, LLC
Lenexa, Kansas, United States
Butchertown Clinical Trials
Louisville, Kentucky, United States
Maine Eye Center (Site 097)
Portland, Maine, United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, United States
Retina Research Institute at New England Retina Consultants, PC
Springfield, Massachusetts, United States
Retina Consultants of Minnesota
Edina, Minnesota, United States
Envision Ocular, LLC
Bloomfield, New Jersey, United States
Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY
Great Neck, New York, United States
Retina Associates of Western NY, PC (Site 051)
Rochester, New York, United States
Asheville Eye Associates, Retina Division (Site 077)
Asheville, North Carolina, United States
NC Retina
Cary, North Carolina, United States
Graystone Eye
Hickory, North Carolina, United States
NC Retina Associates
Wake Forest, North Carolina, United States
Erie Retina Research
Erie, Pennsylvania, United States
Charleston Neuroscience Institute (Site 034)
Beaufort, South Carolina, United States
Palmetto Retina Center
Florence, South Carolina, United States
Charleston Neuroscience Institute
Ladson, South Carolina, United States
Palmetto Retina Center
West Columbia, South Carolina, United States
Southeastern Retina Associates
Hixson, Tennessee, United States
Southeastern Retina Associates (Site 095)
Johnson City, Tennessee, United States
Southeastern Retina Associates, P.C.
Knoxville, Tennessee, United States
Tennessee Retina
Nashville, Tennessee, United States
Retina Consultants of Texas
Bellaire, Texas, United States
Texas Retina Associates
Fort Worth, Texas, United States
Retina Consultants of Texas
Katy, Texas, United States
Austin Retina Associates
Round Rock, Texas, United States
Retina Consultants of Texas
San Antonio, Texas, United States
Austin Retina Associates
San Marcos, Texas, United States
Retina Consultants of Texas
Schertz, Texas, United States
Salt Lake Retina
West Jordan, Utah, United States
Vistar Eye Center (Site 129)
Roanoke, Virginia, United States
Pacific Northwest Retina
Bellevue, Washington, United States
IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia (Site 332)
São Paulo, Brazil
Clinica Oftalmologica del Caribe (COFCA)
Barranquilla, Colombia
Fundacion Oftalmologica Nacional
Bogotá, Colombia
Clinica de Oftalmologia Sandiego
Medellín, Colombia
Klaudians Hospital - Ophthalmology department
Mladá Boleslav, Czechia
VISUS spol. s r.o.
Náchod, Czechia
Axon Clinical, s.r.o. (Site 400)
Prague, Czechia
Hopital Intercommunal De Creteil
Créteil, France