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A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Sponsor: EyeBiotech Ltd.
Summary
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Official title: A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
960
Start Date
2026-04-30
Completion Date
2028-07-31
Last Updated
2026-04-01
Healthy Volunteers
No
Conditions
Interventions
Tiespectus
Administered by intravitreal (IVT) injection
Aflibercept
Administered by intravitreal (IVT) injection