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Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)
Sponsor: Massachusetts Institute of Technology
Summary
Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in dementia. Development of a non-invasive medical device that is effective in slowing cognitive impairment is not only revolutionary but also possibly cost- effective. In this study, participants will come to MIT for a 1-day visit and the investigators will evaluate the effects of GENUS in cognitively normal, healthy adults. Investigators will use Electroencephalogram (EEG), Magnetoencephalography (MEG), magnetic resonance imaging (MRI), neuropsychological testing, and blood sampling in subsets of participants to evaluate for biological effects and safety of GENUS stimulation.
Official title: Pilot Study to Evaluate Feasibility of Sensory Stimulation With Gamma Frequency Entrainment
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2018-02-20
Completion Date
2027-01-30
Last Updated
2026-03-27
Healthy Volunteers
Yes
Interventions
GENUS
The device is a light and sound device that delivers light stimulation using light-emitting diodes (LED) and sound stimulation through a speaker, with a centrally-mounted tablet or phone that plays videos for entertainment. The device will be positioned on an easel such that the tablet is eye level with the participant while they are sitting 5 feet away or held in their hands. The active device delivers light and sound at 40Hz rate.
Tactile GENUS
The device is a wrist worn or hand held device that vibrates or otherwise generates tactile stimulation at specific frequencies.
Locations (1)
MIT
Cambridge, Massachusetts, United States