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Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination (MBOTE-TRAXX): Clinical Study to Monitor the Immunological Response Following Mpox Vaccination in the City of Kinshasa, Democratic Republic of the Congo
Sponsor: Institute of Tropical Medicine, Belgium
Summary
The study Mbote-TRAXX evaluates humoral and cellular immune responses in individuals vaccinated against mpox with the MVA-BN or LC16m8 vaccine administered as part of routine mpox vaccination campaigns in Kinshasa, Democratic Republic of the Congo (DRC). Participants will be followed at multiple time points after vaccination in order to assess the kinetics and durability of the immune response by collection of blood samples. We plan to include approximately 150 participants vaccinated with MVA-BN and 150 participants vaccinated with LC16m8.
Official title: Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2026-04-15
Completion Date
2028-11-15
Last Updated
2026-03-30
Healthy Volunteers
Yes
Conditions
Interventions
blood sample collection
10 mL of blood will be collected at every visit and additional 20 mL blood samples will be taken from a subgroup of participants at every visit.