Clinical Research Directory

Inclusion Criteria: * Adults aged 18 years or older. * Patients attending the Podiatry Clinical Area of the University of Seville. * Presence of musculoskeletal pain in one or both feet at the initial assessment. * Ability to understand the study information and provide written informed consent. * Ability to follow study instructions and complete study assessments. * Intact skin at the application site. Exclusion Criteria: * Foot pain of non-musculoskeletal origin, or pain mainly attributable to infectious, vascular, tumoral, severe neurological, or decompensated systemic diseases. * Wounds, ulcers, burns, dermatitis, skin infections, or any active skin disorder at the application site. * Known allergy, hypersensitivity, or previous adverse reaction to any component of the investigational cream or placebo. * Concomitant use of analgesic, anti-inflammatory, or topical treatments on the foot that may interfere with efficacy assessment, unless a washout period is established. * Recent infiltrations, surgery, or invasive treatment on the foot or ankle that may alter pain evolution during the study. * Pregnancy or breastfeeding.