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A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis
Sponsor: Vertex Pharmaceuticals Incorporated
Summary
The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).
Official title: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With a Long-term Extension of Povetacicept in Adults With Generalized Myasthenia Gravis
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-05-13
Completion Date
2029-03-02
Last Updated
2026-08-03
Healthy Volunteers
No
Conditions
Interventions
Povetacicept
Solution for Subcutaneous Injection.
Placebo
Solution for Subcutaneous Injection.
Locations (26)
Tri Valley Neurology Medical Associates Inc.
Mission Hills, California, United States
Neurology Offices
Boca Raton, Florida, United States
SFM Clinical Reseach, LLC
Boca Raton, Florida, United States
Homestead Associates in Research
Homestead, Florida, United States
UF Health Jacksonville Respiratory Therapy (PFT and DLCO)
Jacksonville, Florida, United States
Y & L Advance Health Care, Inc D/B/A Elite Clinical Research - Neurology
Miami, Florida, United States
Quantix Research
Miami, Florida, United States
Hawaii Pacific Neuroscience
Honolulu, Hawaii, United States
HSHS Medical Group - St. Elizabeth's Hospital
O'Fallon, Illinois, United States
Las Vegas Neurology Center
Las Vegas, Nevada, United States
Clinical Trials of South Carolina - Neurology
Charleston, South Carolina, United States
Ut Erlanger Neurology
Chattanooga, Tennessee, United States
Nerve and Muscle Center of Texas - Neurology
Houston, Texas, United States
Texas Institute for Neurological Disorders
Sherman, Texas, United States
Neurology Care Clinic
Waxahachie, Texas, United States
Eastern Health - Box Hill Hospital
Box Hill, Australia
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, Poland
Neurologia Slaska Centrum Medyczne
Katowice, Poland
Clinical Research Center Sp. z o.o., Medic-R Sp. K.
Poznan, Poland
NZOZ NEURO-KARD Ilkowski i Partnerzy Sp. Partnerska Lekarzy
Poznan, Poland
Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o. o.
Poznan, Poland
Centrum Medyczne Neuroprotect
Warsaw, Poland
ETG Neuroscience
Warsaw, Poland
University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital
Birmingham, United Kingdom
St. George's University Hospital
London, United Kingdom
Northern Care Alliance NHS Foundation Trust - Salford Royal Hospital
Salford, United Kingdom