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Non-invasive Tests for Non-alcoholic Steato-hepatitis
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
The main objective is to study and validate a new approach for NASH and liver fibrosis diagnosis and personalized follow-up based on monocyte biomarkers and plasma metabolites. The investigators will assess if PLIN2 and RAB14 can be used not only to identify subjects with NASH and advanced fibrosis but also for monitoring the effect of treatment alone or in combination with other metabolic parameters
Official title: Non-invasive Blood Tests for the Diagnosis and Therapeutic Monitoring of Non-alcoholic Steato-hepatitis
Key Details
Gender
All
Age Range
25 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
828
Start Date
2024-08-31
Completion Date
2027-02-28
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Interventions
Administration of Deuterated water
A blood sample will be taken in the morning after an overnight fast and after consuming deuterated water (2H2O) (3 g/kg body water) the evening before the study day to achieve a plasma water enrichment of 0.3% for the measurement of DNL
Locations (1)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, Italy