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Standardized Italian netwoRk Enrolling iNdividuals With Islet-Autoantibodies
Sponsor: Società Italiana di Endocrinologia e Diabetologia Pediatrica
Summary
This project characterizes the longitudinal progression of children and adults who have tested positive for one or more islet cell autoantibodies across the early stages of type 1 diabetes (T1D). Despite advances in screening, limited evidence exists on how clinical, metabolic, and immunological markers evolve over time and predict progression to symptomatic disease. Using a screened cohort, participants are followed for up to 10 years with repeated standardized assessments. The study evaluates whether population-based screening can reduce diabetic ketoacidosis (DKA) at diagnosis and identify early predictors of progression to clinical T1D. Results are expected to improve risk stratification, inform surveillance strategies, and guide the timing of preventive interventions, with implications for clinical practice and health policy.
Official title: Standardized Italian netwoRk Enrolling iNdividuals With Islet-Autoantibodies (SIRENA)
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2026-05
Completion Date
2036-04
Last Updated
2026-04-08
Healthy Volunteers
No
Locations (24)
SOD Diabetologia Pediatrica - Azienda Ospedaliero Universitaria delle Marche
Ancona, Italy
Ambulatorio di Diabetologia Pediatrica, UOC Pediatria/Neonatologia Ospedale San Paolo
Bari, Italy
Department of Pediatrics, Hospital of Bolzano (SABES-ASDAA),Teaching Hospital of Paracelsus Medical University
Bolzano, Italy
UOS Diabetologia ed Endocrinologia pediatrica, AORN Sant'Anna e San Sebastiano
Caserta, Italy
UOC Pediatria, Azienza Ospedaliero-Universitaria "Renato Dulbecco"
Catanzaro, Italy
Centro Provinciale di Diabetologia Pediatrica - SOC di Pediatria - Ospedale "S. Giovanni di Dio"
Crotone, Italy
SOC Diabetologia ed Endocrinologia, AOU Meyer IRCCS
Florence, Italy
Università degli Studi dell'Aquila - UO Pediatria e PSP, Ospedale San Salvatore
L’Aquila, Italy
Ospedale S. Raffaele
Milan, Italy
Centro Regionale di Diabetologia Pediatrica, UOC Pediatria Specialistica, Dipartimento ad Attività Integrata Materno Infantile, AOU Federico II
Naples, Italy
Ospedale Maggiore della Carità di Novara
Novara, Italy
Azienda Ospedale-Università Padova
Padova, Italy
Ospedale G.Di Cristina - ARNAS Civico di Cristina Benfratelli
Palermo, Italy
UOC Endocrinologia e Malattie del Metabolismo AOU di Parma
Parma, Italy
IRCCS Policlinico San Matteo, SS Pediatria 2 - Malattie Endocrine / Ambulatorio di Diabetologia Pediatrica
Pavia, Italy
Centro di Diabetologia Pediatrica Grande Ospedale Metropolitano
Reggio Calabria, Italy
Ospedale Pediatrico Bambino Gesù
Roma, Italy
UOC Pediatria, Casa Sollievo della Sofferenza
San Giovanni Rotondo, Italy
S.C. Pediatria, P.O.C SS. Annunziata
Taranto, Italy
Ospedale di Santa Chiara Azienda USL
Trento, Italy
Ospedale S.M. del Ca' Foncello, Treviso, AULSS2 Marca Trevigiana
Treviso, Italy
IRCCS "Ospedale Infantile" Burlo Garofolo
Trieste, Italy
Azienda Ospedaliero Integrata di Verona
Verona, Italy
Centro diabetologico aziendale - UOS Diabetologia pediatrica; ASL Viterbo
Viterbo, Italy