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Trunk Inclination, Positive End-expiratory Pressure, and Lung Recruitability
Sponsor: Zhongda Hospital
Summary
This multicenter, physiological, observational study hypothesizes that in moderate to severe ARDS, trunk inclination unloads the chest wall, but its impact on lung mechanics depends on PEEP levels and lung recruitability.
Official title: Impact of Trunk Inclination on Lung Mechanics According to PEEP and Reruitability
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2026-03-20
Completion Date
2027-04-30
Last Updated
2026-04-01
Healthy Volunteers
No
Interventions
Specific lung recruitment maneuvers and decremental PEEP steps
Specific lung recruitment maneuvers will be performed to measure the potential for lung recruitment. Followed by a decremental PEEP steps to determine lung mechanics at different PEEP levels. These process will be repeated when patients change to another position. Electrical impedance tomography signals, synchronized signals of airway pressure and flow, esophageal pressure will be recorded continuously.
Locations (3)
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, Shandong, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China