Clinical Research Directory

Inclusion Criteria: * 18- to 40-year-old men and women * Consent to participate * Fluent in German * Right-handed * Physically and mentally healthy without regular medication * Body-mass index of 18-25 kg/m2 * Alcohol consumption of less than 15 glasses a week (equivalent to one glass of wine/beer, a glass of higher-percentage alcohol counts as two glasses of beer) * No illegal drug consumption in the week previous to the experiment * No smoking * No competitive athletes * Normal day-night rhythm (no shift work) * Normal vision without required vision correction (i.e., glasses, contact lenses; ability to clearly read texts at a distance of up to 50 cm without vision aids) Exclusion Criteria: * Former or current illnesses of: * Brain or mind (including anxiety disorders, depression, eating disorders, personality disorders, alcohol, drugs or drug dependence, neurological disorders other than occasional headache, psychiatric or neurological abnormalities) * Heart or blood circulation * Lung Diseases * Other serious past or present medical conditions (for example, metabolic syndrome, diabetes) * Current medication and medication over a period of two weeks prior to the examination * Other serious health problems or present strong mental or physical stress * Current infection or excessive stress * Missing consent to receive information about incidental findings from the MRI * Tendency to claustrophobia, dizziness, or panic attacks * Wearing a non-removable pacemaker, defibrillator, hearing aid, drug pump, neurostimulator or implant with solenoid valve (e.g., artificial bowel outlet) * Metal parts or implants inside the body, for example, due to surgery or injury with a metallic foreign object (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coil, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents) * Having non-removable metal parts or metal-containing devices on or in the body * Having ferromagnetic metal parts or implants inside the body (e.g., hip replacements, artificial joints, heart valves, vessel occlusions or dilatations, surgical clips, bone screws or plates, coils, shunts, catheters, electrodes, coils, radiation sources, shrapnel, projectiles, stents) * Wearing magnetically fixed implants (e.g. amalgam fillings, glass eye) * Professionally or privately being involved in the processing of ferromagnetic metals * Large tattoos (whole limbs) * Pregnancy * Wearing an intra-uterine device * Having tinnitus * Extensive lung function (e.g. apnoe diver, singer, professional musician with lung-involving instruments) * Previous participation in the ProlEx-MRI study (the precursor to the current study)