Clinical Research Directory

Inclusion Criteria: * Presentation to the Emergency Department or unscheduled consultation in one of the participating centers * Symptomatic PE objectively confirmed according to the European Society of Cardiology criteria 4 (either by i) a high-probability ventilation/perfusion lung scan, ii) a new contrast filling defect on spiral computed tomography, or iii) a new documentation by ultrasonography of a proximal DVT, i.e., thrombus in the popliteal vein or above, along with clinical signs of PE. All radiological tests used to diagnose PE will be interpreted by on-site radiologists or angiologists) * No clinical criteria mandating hospitalization according to the Hestia rule, i.e., negative Hestia rule * Right ventricular dysfunction - defined as a right ventricular (RV) to left ventricular (LV) diameter ratio \> 1.0 on echocardiography (apical four-chamber or subcostal four-chamber view) or on CTPA (transverse plane) OR High-sensibility cardiac troponin I or T concentration above the upper limit of local normal value * Insurance cover according to local legislation * Age ≥18 years * Signed free informed consent (or oral consent if possible according to local regulation). Exclusion Criteria: * Shock or hypotension (defined as systolic blood pressure \<90 mmHg or a systolic pressure drop by ≥40 mmHg, for \>15 minutes, if not caused by new-onset arrhythmia, hypovolemia, or sepsis) * Combined right ventricular dysfunction (RV/LV \> 1.0 on imaging) AND troponin concentration above the upper limit of local normal value * Free floating thrombi in the right atrium or ventricle, if identified by routine echocardiography or CTPA * Active cancer other than basal or squamous-cell skin cancer defined at least with one of the following: i) cancer diagnosed within the last 6 months, ii) current anti-cancer treatment or during the 6 months before enrollment, iii) locally advanced or metastatic cancer * PE diagnosis established since more than 24 hours * 48 hours or more elapsed between ED presentation and potential inclusion or other reason making home discharge impossible within the 48 hours since ED presentation * Limited life expectancy or any other reason making 3-month follow-up impossible * Pregnant or parturient patient * Patient in detention by judicial or administrative decision, under a legal protection measure or undergoing compulsory psychiatric treatment