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Pancreatic Polypeptide as a Modulator of Amylin- Induced Satiety in Healthy Humans
Sponsor: University Hospital, Gentofte, Copenhagen
Summary
The two pancreatic hormones amylin and pancreatic polypeptide (PP) has been linked to satiety and energy metabolism. The goal of this this study is to determine the separate and combined effects of the two hormones on food intake and other exploratory endpoints related to metabolism in healthy humans. The aim of this study is to investigate the interaction between the hormones and obtain insight into the physiology of the hormones. The healthy participants will undergo 4 study days in a randomised order receiving the following infusions for 5 hours: A) Amylin + PP B) Amylin + Placebo C) Placebo + PP D) Placebo + Placebo Throughout the day blood samples will be collected and gallbladder motility will be evaluated. Further, indirect calorimetry and heart rate/blood pressure measurement will be performed.
Key Details
Gender
MALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2026-04
Completion Date
2028-10
Last Updated
2026-04-01
Healthy Volunteers
Yes
Conditions
Interventions
Amylin (Pramlintide)
This a one of the pancreatic hormones investigated in this study. Pramlintide is used a surrogate for amylin due to the fibrillating properties of amylin
Pancreatic Polypeptide (PP)
This a one of the pancreatic hormones investigated in this study.
Placebo (NaCl 0.9 % solution)
This the placebo
Locations (1)
Center for Clinical Metabolic Research, Gentofte Hospital
Hellerup, Capital Region, Denmark