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Performance of the Treatment of Periodontitis According to the Bioperio® Protocol
Sponsor: University of Pisa
Summary
This multicenter, prospective, single-arm observational study evaluated the 3-month clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III/IV cases-adjunctive enamel matrix derivative application in deep pockets.
Official title: Performance of the Treatment of Periodontitis According to the Bioperio® Protocol: a Prospective Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2023-12-05
Completion Date
2030-12-05
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
periodontal probing and charting
All clinical periodontal parameters were assessed at baseline and at the 3-month follow-up by calibrated examiners. Probing Instrument: A manual periodontal probe (UNC 15, Hu-Friedy, Chicago, IL, USA) was used. Examiners were calibrated to apply a consistent probing force of 0.25 N using a force-measuring scale. Measurements: For each tooth, six sites were examined: mesiobuccal, mid-buccal, distobuccal, mesiolingual, mid-lingual, and distolingual. Probing Pocket Depth (PPD): Measured in millimeters from the gingival margin to the base of the pocket; rounded to the nearest millimeter. Gingival Recession (REC): Measured in millimeters from the cementoenamel junction to the gingival margin; recorded as a positive value when the gingival margin was apical to the cementoenamel junction. Clinical Attachment Level (CAL): Calculated as PPD + REC for each site. Bleeding on Probing (BOP): Recorded dichotomously (present/absent) at the same six sites per tooth. The full-mouth bleeding score
Locations (1)
University of Pisa
Pisa, None Selected, Italy