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Probiotics for Constipation Relief in Adults
Sponsor: Wecare Probiotics Co., Ltd.
Summary
This study aims to evaluate the efficacy and safety of Bifidobacterium animalis subsp. lactis BLa36 in adults with functional constipation. In this randomized, double-blind, placebo-controlled trial, participants will receive BLa36 supplementation or placebo for 4 weeks. Clinical outcomes will be assessed using validated gastrointestinal symptom scales, stool characteristics, and quality-of-life measures. In addition, changes in inflammatory and immune markers, gut microbiota composition, metabolic indicators, and gut-brain axis-related parameters will be evaluated to comprehensively determine the effects of BLa36 on intestinal function and overall health.
Official title: Efficacy and Safety of Bifidobacterium Animalis Subsp. Lactis BLa36 on Gastrointestinal Function, Inflammatory and Immune Responses, and Gut Microbiota in Adults With Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2026-04-15
Completion Date
2027-01-20
Last Updated
2026-04-02
Healthy Volunteers
Yes
Conditions
Interventions
Probiotic
BLa36 will be administered orally once daily for 8 weeks. Follow-up assessments will be conducted at Week 0, Week 4, and Week 8.
Maltodextrin
Maltodextrin will be administered orally once daily for 8 weeks. Follow-up assessments will be conducted at Week 0, Week 4, and Week 8.
Locations (1)
Suzhou Ninth People's Hospital
Suzhou, Jiangsu, China