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Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome
Sponsor: Punjab Institute of Cardology
Summary
The goal of this clinical trial is to evaluate whether triple lipid-lowering therapy (atorvastatin, ezetimibe, and bempedoic acid) is more effective than dual therapy (atorvastatin and ezetimibe) in reducing LDL cholesterol levels in adults with acute coronary syndrome. It will also assess the safety of the treatment. The main questions it aims to answer are: * Does triple therapy result in greater reduction in LDL-C compared to dual therapy? * What adverse effects occur in participants receiving triple therapy? Researchers will compare triple therapy to dual therapy to determine its effectiveness in lowering LDL-C levels. Participants will: * Receive either dual or triple lipid-lowering therapy for 3 months * Attend regular follow-up visits for clinical assessment and laboratory testing * Undergo lipid profile evaluation at baseline and at the end of the study
Official title: Triple (Atorvastatin, Ezetimibe, and Bempedoic Acid) Versus Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-05-01
Completion Date
2026-10-31
Last Updated
2026-04-09
Healthy Volunteers
No
Interventions
Atorvastatin 40 Mg Oral Tablet
Atorvastatin administered orally once daily as part of lipid-lowering therapy
Ezetimibe 10 mg
Ezetimibe administered orally once daily to reduce cholesterol absorption
Bempedoic Acid 180 MG Oral Tablet
Bempedoic acid administered orally once daily as an adjunct lipid-lowering agent
Locations (1)
Punjab Institute of Cardiology
Lahore, Punjab Province, Pakistan