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NOT YET RECRUITING
NCT07508254
PHASE4

Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome

Sponsor: Punjab Institute of Cardology

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to evaluate whether triple lipid-lowering therapy (atorvastatin, ezetimibe, and bempedoic acid) is more effective than dual therapy (atorvastatin and ezetimibe) in reducing LDL cholesterol levels in adults with acute coronary syndrome. It will also assess the safety of the treatment. The main questions it aims to answer are: * Does triple therapy result in greater reduction in LDL-C compared to dual therapy? * What adverse effects occur in participants receiving triple therapy? Researchers will compare triple therapy to dual therapy to determine its effectiveness in lowering LDL-C levels. Participants will: * Receive either dual or triple lipid-lowering therapy for 3 months * Attend regular follow-up visits for clinical assessment and laboratory testing * Undergo lipid profile evaluation at baseline and at the end of the study

Official title: Triple (Atorvastatin, Ezetimibe, and Bempedoic Acid) Versus Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome: A Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2026-05-01

Completion Date

2026-10-31

Last Updated

2026-04-09

Healthy Volunteers

No

Interventions

DRUG

Atorvastatin 40 Mg Oral Tablet

Atorvastatin administered orally once daily as part of lipid-lowering therapy

DRUG

Ezetimibe 10 mg

Ezetimibe administered orally once daily to reduce cholesterol absorption

DRUG

Bempedoic Acid 180 MG Oral Tablet

Bempedoic acid administered orally once daily as an adjunct lipid-lowering agent

Locations (1)

Punjab Institute of Cardiology

Lahore, Punjab Province, Pakistan