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NOT YET RECRUITING
NCT07509307
PHASE3

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Official title: Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 6)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

400

Start Date

2026-04-13

Completion Date

2028-07-17

Last Updated

2026-04-03

Healthy Volunteers

No

Interventions

DRUG

NNC0487-0111

NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

DRUG

Placebo (matched to NNC0487-0111)

Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.

Locations (78)

Neighborhood Healthcare

Escondido, California, United States

First Valley Medical Group

Lancaster, California, United States

Desert Oasis Healthcare

Palm Springs, California, United States

Chase Medical Research LLC

Waterbury, Connecticut, United States

Westside Center For Clinical Research

Jacksonville, Florida, United States

CNS Healthcare

Jacksonville, Florida, United States

Advanced Res for Health Improve

Naples, Florida, United States

Clinical Investigation Spec Gurnee

Gurnee, Illinois, United States

Evanston Premier Hlthcr Res

Skokie, Illinois, United States

Monroe Biomedical Research, LLC

Louisville, Kentucky, United States

Arcturus Healthcare, PLC.

Troy, Michigan, United States

Clinvest Research

Springfield, Missouri, United States

NYU Langone Health

New York, New York, United States

Hospital For Special Surgery

New York, New York, United States

Piedmont Healthcare/Research

Statesville, North Carolina, United States

Northwest Research Center

Portland, Oregon, United States

Mercy Family Clinic

Dallas, Texas, United States

Health Res of Hampton Roads

Newport News, Virginia, United States

Northwest Clinical Research Center

Bellevue, Washington, United States

Emeritus Research Sydney

Botany, New South Wales, Australia

Momentum Clinical Research Darlinghurst

Darlinghurst, New South Wales, Australia

Kolling Institute

St Leonards, New South Wales, Australia

Heart of Australia

Chelmer, Queensland, Australia

Coastal Digestive Health

Maroochydore, Queensland, Australia

UMHAT Sveti Georgi EAD, Plovdiv

Plovdiv, Bulgaria

MC Dr. Atanasov EOOD

Sofia, Bulgaria

MC Excelsior OOD

Sofia, Bulgaria

UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology

Sofia, Bulgaria

MMA MHAT - Sofia, Rheumatology clinic

Sofia, Bulgaria

UMHAT Sveti Ivan Rilski EAD, Rheumatology

Sofia, Bulgaria

TLC Diabetes and Endocrinology

Surrey, British Columbia, Canada

Your Research Network

Niagara Falls, Ontario, Canada

ALPHA Recherche Clinique

Lévis, Quebec, Canada

Centre Medical Acadie

Montreal, Quebec, Canada

ALPHA Recherche Clinique

Québec, Quebec, Canada

Centre de Recherche du CHUS

Sherbrooke, Quebec, Canada

Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme

Aarhus N, Denmark

Frederiksberg Hospital - Parker Institutet (Artrose)

Frederiksberg, Denmark

Sanos Clinic - Herlev

Herlev, Denmark

University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine

Chaïdári, Attica, Greece

Evangelismos S.A. - Endocrinology department

Athens, Greece

Laiko General Hospital Of Athens - 1st department of Internal Medicine

Athens, Greece

Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases

Athens, Greece

Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

Marousi, Greece

NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

Thessaloniki, Greece

Thermi Clinic S.A. - Diabetes and Internal Medicine Department

Thessaloniki, Greece

Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo

Udine, Friuli Venezia Giulia, Italy

Casa della Salute di Ceccano - Ambulatori Campus Biomedico

Rome, Lazio, Italy

Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

Rome, Lazio, Italy

Auxologico San Luca - Endocrinologia e Malattie del Metabolismo

Milan, Lombardy, Italy

Ospedale Galeazzi S.p.A. - INCO - Istituto Nazionale per la Cura dell'Obesità

Milan, Lombardy, Italy

Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica

San Donato Milanese, Lombardy, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia

Verona, Veneto, Italy

"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

Bialystok, Podlaskie Voivodeship, Poland

ClinicMed Daniluk, Nowak Spółka Komandytowa

Bialystok, Poland

Centrum Medyczne Intercor Sp. z o.o.

Bydgoszcz, Poland

CenterMed Kraków Sp. z o.o.

Krakow, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.

Krakow, Poland

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

Warsaw, Poland

Latin Clinical Trial Center Puerto Rico

San Juan, Puerto Rico

Instituto Medico Quirurgico San Rafael

A Coruña, Spain

Hospital Germans Trias i Pujol

Badalona, Spain

Hospital Naval Ferrol

Ferrol, Spain

Centro Especialidades Hermanos Sangro

Madrid, Spain

Hospital Quirónsalud Málaga

Málaga, Spain

Hospital Infanta Sofía

San Sebastián de Los Reyes (Madrid), Spain

Hospital Universitario Marqués de Valdecilla

Santander, Spain

Hospital HM La Esperanza

Santiago de Compostela, Spain

Clínica Nuevas Tecnologías en Diabetes y Endocrinología

Seville, Spain

H. Infanta Luisa_Endocrino y Obesidad

Seville, Spain

Hospital General de Valencia

Valencia, Spain

İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi

Bahçelievler/İstanbul, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon

Çankaya/Ankara, Turkey (Türkiye)

SBÜ Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştırma Hastanesi

Çankaya/Ankara, Turkey (Türkiye)

Trakya Üniversitesi Tıp Fakültesi Hastanesi-Fizik Tedavi ve Rehabilitasyon

Edirne, Turkey (Türkiye)

Istanbul Üniversitesi- Istanbul Tıp Fakültesi Esnaf Hastanesi Poliklinikleri Fiziksel Tıp Ve Rehabilitasyon Anabilim Dalı

Fatih/İstanbul, Turkey (Türkiye)

Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

Yuregir/Adana, Turkey (Türkiye)

Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon

Yıldırım/Bursa, Turkey (Türkiye)