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Prospective Exploratory Study of a Multiomic Blood Biomarker Panel to Predict Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Sponsor: Centre Hospitalier de Bligny
Summary
The goal of this prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months is to identify biomarkers to predict the overall occurrence of chronic chemotherapy-induced peripheral neuropathy (CIPN, any grade), in each of two treatment subgroups (taxanes and oxaliplatin). It involves integration of clinical data and plasma multiomic biomarkers (proteomic + metabolomic panel) analyzed via supervised machine learning to identify predictive features of CIPN.
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
192
Start Date
2027-01-04
Completion Date
2029-06-04
Last Updated
2026-04-06
Healthy Volunteers
No
Conditions
Interventions
longitudinal blood sampling and standardized neurological evaluation over 6 months
Prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months